The authors of this study were led by Dr. Emily T. Joffe. She is the Chair and Co-Founder of the Center for Translational Research in Cardiovascular Research (CIRC) at the Johns Hopkins University School of Medicine. This is a research project that has been in constant demand for years for the study of chronic obstructive pulmonary disease (COPD), particularly for lung cancer, and the recent use of a combination of high-dose methotrexate and a low-dose ciprofloxacin has shown promise for lung cancer prevention.
To assess the clinical response of CIRC’s Cefixime™, which is a combination of ciprofloxacin and methotrexate, a potent and selective inhibitor of CYP2D6, to the patients’ clinical outcomes in the ICU setting, we examined a large cohort of patients receiving CIRC. This study was designed to provide the largest data set of patients for the purpose of the CIRC study, and we also assessed the outcomes of patients with CIRC treated with methotrexate for more than 12 weeks. In this study, patients with advanced lung cancer received CIRC and methotrexate treatment for 10 weeks, and the incidence of adverse events was significantly increased by ciprofloxacin. CIRC had a significantly higher incidence of adverse events (14.7% of patients) compared with methotrexate and metformin, and the absolute risk of events was significantly higher than the other coadministration groups. The rate of adverse events was similar in the CIRC and methotrexate groups, and the absolute risk of events was not significantly different between the two groups.
The investigators, Dr. T. Joffe, recruited a large, randomized, controlled, multisite, multicentre, double blind study to investigate the long-term effects of CIRC in the ICU setting. The study began as a prospective study and included 732 patients with lung cancer receiving CIRC, methotrexate, or ciprofloxacin. After 10 weeks, the investigators collected data from all patients, including a baseline assessment of patient status and any adverse events. The primary endpoint was the time to death, followed by a composite of the following outcomes: the time to first dose of CIRC or methotrexate treatment, the time to recurrence, and the time to a recurrence event. Secondary endpoints included changes in the quality of life (QoL) as measured by the investigator-assessed International Prostate Symptom Score (IPSS) and Global Respiratory Function Index (GFR). The investigators then performed a secondary analysis of the primary endpoint, which was the change in IPSS, GFR, and QoL. The investigators also performed a multivariable analysis, which included the time to recurrence and the time to a recurrence event and CIRC as well as methotrexate, metformin, and ciprofloxacin. The investigators concluded that CIRC is a safe and effective treatment for lung cancer patients with COPD, and that methotrexate and CIRC have comparable efficacy rates to CIPD. However, this study is an important first step for the development of CIRC and methotrexate treatment, and it will help to improve the overall health care of patients with lung cancer.
Keywords:COPD; Ciprofloxacin; Methotrexate; ICU; Interim study; Quality of Life
In this study, we used a combination of high-dose methotrexate (CIPD) and a low-dose ciprofloxacin to evaluate the effect of CIRC on patients’ clinical outcomes in the ICU setting. The primary outcome was the time to death, followed by a composite of the time to recurrence and a time to a recurrence event. Secondary outcomes included changes in the quality of life (QoL) as measured by the investigator-assessed International Prostate Symptom Score (IPSS) and Global Respiratory Function Index (GFR). Joffe, recruited a large, randomized, controlled, multisite, multicentre, multisite, multicentre, double blind study to investigate the long-term effects of CIRC in the ICU setting.Tip:Do not touch the dropper to any surface, including the surface of your pet's eye.
| Dosage for Cats, Dogs & Horses | |
|---|---|
| Weight | Dosage |
| All weights | Use as prescribed by your veterinarian. |
Safe use in pregnant pets or pets intended for breeding has not been proven. If your pet's condition worsens or does not improve, stop product administration and consult your veterinarian. Ciprofloxacin Hydrochloride Ophthalmic Solution 0.3% is for topical ophthalmic use only. It is not for injection into the eye. Sensitivity to topically applied aminoglycosides may occur in some pets. If your pet has a reaction to Ciprofloxacin Hydrochloride Ophthalmic Solution 0.3%, discontinue use and consult your veterinarian.
Store at 36°-77°F (2°-25°C).
A history of hypersensitivity to ciprofloxacin or any other component of the medication is a contraindication to its use. A history of hypersensitivity to other quinolones may also contraindicate the use of ciprofloxacin.
Not for Injection into the Eye.
Serious and occasionally fatal hypersensitivity (anaphylactic) reactions, some following the first dose, have been reported in patients receiving systemic quinolone therapy. Some reactions were accompanied by cardiovascular collapse, loss of consciousness, tingling, pharyngeal or facial edema, dyspnea, urticaria, and itching. Only a few patients had a history of hypersensitivity reactions. Serious anaphylactic reactions require immediate emergency treatment with epinephrine and other resuscitation measures, including oxygen, intravenous fluids, intravenous antihistamines, corticosteroids, pressor amines and airway management, as clinically indicated.
Remove contact lenses before using.
This medication may interfere with the response and may increase the risk of allergic reactions in people with diabetes. Ask your veterinarian if your pet is comfortable or if you would like to place an order.Ciprofloxacin Hydrochloride Ophthalmic Solution 0.3% is not intended for use in children. For safer, more effective options, consult the guide provided by the veterinarian. As with all drugs, close monitoring of dosage is recommended.
This product has been prescribed by a veterinary medical professional.If you have experience of using the medication for itching or discomfort, please contact the manufacturer for a veterinary supply.
This product has been prescribed by a Pharmacist- For Injection into the eye (E. L. D.®) - E. D.® (Examining the Effect of Listerine Cream on Efficacy of Efficacy of Efficacy of Efficacy of Efficacy of Efficacy of Efficacy of Efficacy of Efficacy of Effect) - Corticosteroids - Use with Metoprolol to Reduce Hypersensitivity.
Cipro has been shown to cause some side effects. Talk to your health care provider if these mild reactions do not go away within a few days.
Common side effects reported from Cipro use include:
This is not a complete list of adverse reactions caused by Cipro.Call your doctor immediately if you experience the following:
Taking Cipro has been shown to impact your tendons (cords attaching bone to your muscles). It can increase your risk of developing tendonitis or a tendon rupture, especially if you’re over 60, taking steroid medications, or have a history of tendon problems.
Cipro can interact with other medications and substances, causing potentially serious side effects or allergic reactions. Tell your doctor if you are taking muscle relaxers such as tizanidine (Zanaflex), phosphodiesterase 5 (PDE5) inhibitors such as sildenafil, anticoagulants (blood thinners), antidepressants, antipsychotics, diuretics, insulin, nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen.
This is not a complete list of Cipro drug interactions, so discuss any medications you’re on, even if you don’t see them listed here. Cipro can cause low blood sugar in some patients. Be wary of low blood pressure symptoms such as blurred vision, fatigue, confusion, pale skin, and cold sweats. Watch for these adverse effects if you have diabetes, and take diabetes medication orally. These could be signs of hypoglycemia and could lead to unconsciousness.
The U. S. Food and Drug Administration (FDA) has found that, while rare, fluoroquinolone antibiotics like Cipro can increase the occurrence of severe ruptures or tears in your aorta (a large artery that begins in the heart). These ruptures can lead to dangerous aortic bleeding, a heart attack, or even death, so people at risk for cardiac problems should be cautious about taking Cipro.
Be sure to tell your doctor if you have been diagnosed with or have a history of other medical conditions, including a prolonged QT interval (a rare heart problem that may cause an irregular heartbeat, fainting, or sudden death), aneurysms, kidney disease, liver disease, heart disease, myasthenia gravis (severe muscle weakness), seizures, or diabetes. Cipro can also significantly increase theophylline levels in your blood, leading to serious illness or death. This is not a comprehensive list of medical conditions that Cipro may affect, so speak with your doctor about your medical history before taking Cipro.
Cipro can cause your skin to become sensitive to sunlight or ultraviolet light, so try to avoid unnecessary sun exposure and do your best to wear protective clothing, sunglasses, or sunscreen that is SPF 15 or higher. Call your doctor if you notice redness, swelling, or blistering from sun exposure while on Cipro.
As with all prescription medication, inform the prescribing doctor about any medical conditions you have been diagnosed with and any medications or supplements you currently take before starting treatment. Antacids can reduce the amount of Cipro that your body absorbs, so be sure to take them at least 2 hours before or 6 hours after taking antacid medications.
In addition, let your doctor know if you are breastfeeding, pregnant, or planning on becoming pregnant before starting treatment with this medication.
We are the caring and help much appreciatedSildenafil is the generic for cipro.Salt Composition in both
Salt Composition
Ciprofloxacin 500mg(same for both)
You Searched
Strip of 10 tablets
We only sell the best substitute from top brands
Our Recommendation
Floxip 500mg Tablet 10s
5,arro Tablet 10s
4,arro Tablet 10s
PlatinumRx is dedicated to delivering dependable and trustworthy information to empower our customers. However, the information presented here is solely for general informational purposes and should not be utilized for diagnosing, preventing, or treating health issues. It is not intended to establish a doctor-patient relationship or serve as a substitute for professional medical advice.
Pantosec DSR 30/40mg PR Capsule 10sPantosec 40mg Tablet 10sCipvildin M 500/50mg Tablet 15sAb Roocil DSR 30/40mg PR Capsule 15sCipcal D3 60000IU Capsule 3sCipcal 500mg/250IU Tablet 15sDapaquest 10mg Tablet 10sMontecip LC 5/10mg Tablet 10sLipvas Dydrogesteran 10mg Tablet 10sParacip 650mg Tablet 10sView More
Aerolife inhalation Device 1sAir Space Wit Exhle Valve Device 1sBp Monitor (Omron) Hem 8712 Device 1sContour Plus System 1sDigital Thermometer Mercury Device 1sDuohaler DPI Device 1sIbreathe DPI Inhealer Device 1sMachaler DPI Device 1sMacspacer Device 1sNovopen 4 | Diabetes Monitoring Devices 1s
Must be:Sr. Member
All trademarks and company names are the property of their original use. The sr is not to be taken, leased, or used in any way without first consulting his/her doctor. This product has been mentioned in any way as the product shows. Do not use this product if you are allergic to any of the components it contains. Also, do not smoke or do not smoke before using this medicine. Contact your doctor or health care adviser for more details.Ciprofloxacin 500mg tablets are an antibiotic medication that is used to treat a wide variety of bacterial infections. It is commonly prescribed to treat respiratory, skin, and urinary tract infections, usually due to its effectiveness and relatively low cost. Ciprofloxacin, also known as ciprofloxacin, belongs to a class of antibiotics known as fluoroquinolones. It works by killing or reducing the growth of bacteria, which reduces the severity of the infection.
Ciprofloxacin 500mg and Floxin are both types of antibiotics that treat a wide variety of bacterial infections, including respiratory and urinary tract infections.
Stade de France Pharmacy